Current Studies at the LLDRC and our Affiliates

StudyDescriptionPrincipal InvestigatorRecruiting
LATTICE: Lithium as a Treatment to Prevent Cognitive Impairment in EldersLearn whether lithium can slow down memory loss or help to prevent Alzheimer’s disease (AD) in people with mild memory problems, specifically those with mild cognitive impairment. Ariel Gildengers, M.D. Yes
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OPTIMUM: Optimizing Depression Treatment in Older AdultsThis study examines the comparative benefits and risks of antidepressant strategies (augmentation and switching) in older adults with TRDEric Lenze, M.D., Jordan Karp, M.D. (local P.I.)No
OPTIMUM -NEUROThis study maps neurocognitive and neuroimaging biomarkers associated with progression to dementia in people with persistent LLD (i.e., TRLLD) compared to those whose LLD remits with treatment.Meryl Butters, Ph.D.No
OPTIMUM Suicide SupplementThis study examines the relationship between suicide risk and brain health in a large group of patients with treatment-resistant late-life depression (TRLLD).Jordan Karp, M.D.No
PREDICTOR: Pharmacy Identification and Primary Care Intervention of Older
Adults at Risk for Suicide
We will identify strategies that can potentially help both patients and physicians: engaging pharmacists in focused screening of older customers flagged for receiving prescriptions for both an opioid analgesic and an antidepressant, and implementing a mental health consultation approach that blends psychiatric decision support for the PCP with care coordination.Jordan Karp, M.D. No
WELL: Widowed Elders’ Lifestyle after LossThe goal of this study is to test the feasibility of a behavioral intervention that uses technology and motivational health coaching to encourage a regular routine of healthy eating, sleeping, and physical activity among older adults who are at high-risk for depression following the death of their spouse.  Sarah Stahl, Ph.D.Yes