Current Studies at the LLDRC and our Affiliates
| Study | Description | Principal Investigator | Recruiting Participants |
|---|---|---|---|
| LATTICE: Lithium as a Treatment to Prevent Cognitive Impairment in Elders | Learn whether lithium can slow down memory loss or help to prevent Alzheimer’s disease (AD) in people with mild memory problems, specifically those with mild cognitive impairment. | Ariel Gildengers, M.D. | Yes Click for more information |
| OPTIMUM: Optimizing Depression Treatment in Older Adults | This study examines the comparative benefits and risks of antidepressant strategies (augmentation and switching) in older adults with TRD | Eric Lenze, M.D., Jordan Karp, M.D. (local P.I.) | No |
| OPTIMUM -NEURO | This study maps neurocognitive and neuroimaging biomarkers associated with progression to dementia in people with persistent LLD (i.e., TRLLD) compared to those whose LLD remits with treatment. | Meryl Butters, Ph.D. | No |
| OPTIMUM Suicide Supplement | This study examines the relationship between suicide risk and brain health in a large group of patients with treatment-resistant late-life depression (TRLLD). | Jordan Karp, M.D. | No |
| PREDICTOR: Pharmacy Identification and Primary Care Intervention of Older Adults at Risk for Suicide | We will identify strategies that can potentially help both patients and physicians: engaging pharmacists in focused screening of older customers flagged for receiving prescriptions for both an opioid analgesic and an antidepressant, and implementing a mental health consultation approach that blends psychiatric decision support for the PCP with care coordination. | Jordan Karp, M.D. | No |
| WELL: Widowed Elders’ Lifestyle after Loss | The goal of this study is to test the feasibility of a behavioral intervention that uses technology and motivational health coaching to encourage a regular routine of healthy eating, sleeping, and physical activity among older adults who are at high-risk for depression following the death of their spouse. | Sarah Stahl, Ph.D. | Yes |
